Endothelin system: the double-edged sword in health and disease.

@article{Kedzierski2001EndothelinST,
  title={Endothelin system: the double-edged sword in health and disease.},
  author={Rafal M Kedzierski and Masashi Yanagisawa},
  journal={Annual review of pharmacology and toxicology},
  year={2001},
  volume={41},
  pages={
          851-76
        }
}
The endothelin system consists of two G-protein-coupled receptors, three peptide ligands, and two activating peptidases. Its pharmacological complexity is reflected by the diverse expression pattern of endothelin system components, which have a variety of physiological and pathophysiological roles. In the vessels, the endothelin system has a basal vasoconstricting role and participates in the development of diseases such as hypertension, atherosclerosis, and vasospasm after subarachnoid… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 336 CITATIONS, ESTIMATED 43% COVERAGE

Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2015
VIEW 15 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Na(x) Channel: What It Is and What It Does.

  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.

  • The Journal of clinical investigation
  • 2014
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 43 Highly Influenced Citations

  • Averaged 12 Citations per year from 2017 through 2019