Endothelin stimulates osteoblastic production of IL-6 but not macrophage colony-stimulating factor.

@article{Perkins1997EndothelinSO,
  title={Endothelin stimulates osteoblastic production of IL-6 but not macrophage colony-stimulating factor.},
  author={Sherrie L. Perkins and Eyad El Sarraj and Stephen J. Kling and Donald E Kohan},
  journal={The American journal of physiology},
  year={1997},
  volume={272 3 Pt 1},
  pages={E461-8}
}
Endothelins (ET) are vasoactive polypeptide hormones that stimulate osteoblastic signal transduction events. Using MC3T3-E1 and primary osteoblasts, we studied ET effects on interleukin-6 (IL-6) and macrophage colony-stimulating factor (M-CSF) production. Enzyme-linked immunosorbent assay analysis showed a dose-dependent 3- to 3.5-fold increase in IL-6 with 100 nM ET-1 stimulation within 4 (primary osteoblasts) to 8 (MC3T3-E1) h. ET-3 was less effective at enhancing IL-6 production, with a… CONTINUE READING