Endothelin stimulates PDGF secretion in cultured human mesangial cells.

  title={Endothelin stimulates PDGF secretion in cultured human mesangial cells.},
  author={F E Jaffer and T C Knauss and Earl Poptic and Hanna Emily Abboud},
  journal={Kidney international},
  volume={38 6},
Endothelin, a 17-DKa peptide originally described as a potent vasoconstrictor, also stimulates the release of important regulators of glomerular hemodynamics such as atrial natriuretic factor and renin. In the present study we investigated the role of endothelin in the release of another potent vasoconstrictor and mitogen of human mesangial cells, the platelet-derived growth factor. Endothelin stimulated PDGF release at 12 hours and the effect was sustained for 36 hours. This effect was… CONTINUE READING


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