Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors.

@article{Brown1989EndothelinSD,
  title={Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors.},
  author={Kevin Brown and Chris Littlewood},
  journal={The Biochemical journal},
  year={1989},
  volume={263 3},
  pages={977-80}
}
The vasoactive peptide endothelin is shown to be a potent mitogen for Swiss 3T3 cells. Although endothelin has little effect on DNA synthesis when added alone to cells in serum-free medium, the peptide synergizes very strongly with several other growth factors. A half-maximal response to endothelin is observed at approx. 0.3 nM, with a maximal effect at 3 nM. Over the same concentration range, endothelin stimulates a 2-fold increase in the accumulation of cellular inositol phosphates… CONTINUE READING
27 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…