Endothelin signalling in the cardiac myocyte and its pathophysiological relevance.

  title={Endothelin signalling in the cardiac myocyte and its pathophysiological relevance.},
  author={Peter H. Sugden and Angela Clerk},
  journal={Current vascular pharmacology},
  volume={3 4},
Endothelin A (ET(A)) transmembrane receptors predominate in rat cardiac myocytes. These are G protein-coupled receptors whose actions are mediated by the G(q) heterotrimeric G proteins. Through these, ET-1 binding to ET(A)-receptors stimulates the hydrolysis of membrane phosphatidylinositol 4,5-bisphosphate to diacylglycerol and inositol 1,4,5-trisphosphate. Diacylglycerol remains in the membrane whereas inositol 1,4,5-trisphosphate is soluble (though its importance in the cardiac myocyte is… CONTINUE READING


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