Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms

@article{Kim2013EndothelinRN,
  title={Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms},
  author={Ki-sung Kim and Yuichiro Arima and Taro Kitazawa and Koichi Nishiyama and Rieko Asai and Yasunobu Uchijima and T Sato and Giovanni Levi and Sachiko Kitanaka and Takashi Igarashi and Yukiko Kurihara and Hiroki Kurihara},
  journal={Mechanisms of Development},
  year={2013},
  volume={130},
  pages={553-566}
}
Endothelin-1 (Edn1), originally identified as a vasoconstrictor peptide, is involved in the development of cranial/cardiac neural crest-derived tissues and organs. In craniofacial development, Edn1 binds to Endothelin type-A receptor (Ednra) to induce homeobox genes Dlx5/Dlx6 and determines the mandibular identity in the first pharyngeal arch. However, it remains unsolved whether this pathway is also critical for pharyngeal arch artery development to form thoracic arteries. Here, we show that… CONTINUE READING

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