Endothelin receptors in cultured and native human radial artery smooth muscle.

@article{Conant2002EndothelinRI,
  title={Endothelin receptors in cultured and native human radial artery smooth muscle.},
  author={Alan R Conant and Aung Ye Oo and Michael Richard Dashwood and Karen Collard and Michael R Chester and Walid C Dihmis and Alec W. M. Simpson},
  journal={Journal of cardiovascular pharmacology},
  year={2002},
  volume={39 1},
  pages={130-41}
}
In human vascular smooth muscle cells endothelin-1, acting at both endothelin A and endothelin B receptors, has been demonstrated to be both a potent vasoconstrictor and mitogen. Our aim was to study the functional expression of endothelin receptors in human radial artery smooth muscle using both native tissue and cultured cells (RASMCs). Radial artery smooth muscle cells were cultured from arterial explants and loaded with the calcium fluorescent dye fura-2. Cells responded to endothelin-1 and… CONTINUE READING