Endothelin receptors as novel targets in tumor therapy

  title={Endothelin receptors as novel targets in tumor therapy},
  author={Anna Bagnato and Pier Giorgio Natali},
  journal={Journal of Translational Medicine},
  pages={16 - 16}
The endotelin (ET) axis, that includes ET-1, ET-2, ET-3, and the ET receptors, ETA and ETB, plays an important physiological role, as modulator of vasomotor tone, tissue differentiation and development, cell proliferation, and hormone production. Recently, investigations into the role of the ET axis in mitogenesis, apoptosis inhibition, invasiveness, angiogenesis and bone remodeling have provided evidence of the importance of the ET-1 axis in cancer. Data suggest that ET-1 participates in the… CONTINUE READING


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