Endothelin receptors as novel targets in tumor therapy

@article{Bagnato2004EndothelinRA,
  title={Endothelin receptors as novel targets in tumor therapy},
  author={Anna Bagnato and Pier Giorgio Natali},
  journal={Journal of Translational Medicine},
  year={2004},
  volume={2},
  pages={16 - 16}
}
The endotelin (ET) axis, that includes ET-1, ET-2, ET-3, and the ET receptors, ETA and ETB, plays an important physiological role, as modulator of vasomotor tone, tissue differentiation and development, cell proliferation, and hormone production. Recently, investigations into the role of the ET axis in mitogenesis, apoptosis inhibition, invasiveness, angiogenesis and bone remodeling have provided evidence of the importance of the ET-1 axis in cancer. Data suggest that ET-1 participates in the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 58 references

Role of endothelin-1 in neovascularization of ovarian carcinoma

D Salani, V Di Castro, +5 authors A Bagnato
Am J Pathol • 2000
View 3 Excerpts
Highly Influenced

Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004
View 1 Excerpt

Targeting endothelin axis in cancer.

Cancer treatment and research • 2004
View 1 Excerpt

A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 2 Excerpts

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