Endothelin receptor pathway in human left ventricular myocytes: relation to contractility.

BACKGROUND Increased synthesis and release of the potent bioactive peptide endothelin-1 (ET-1) occurs during and after cardiac surgery. However, the cellular and molecular basis for the effects of ET-1 on human left ventricular (LV) myocyte contractility remains unknown. METHODS LV myocyte contractility was examined from myocardial biopsies taken from… CONTINUE READING