Endothelin receptor blockade in canine oleic acid-induced lung injury

@article{Hubloue2003EndothelinRB,
  title={Endothelin receptor blockade in canine oleic acid-induced lung injury},
  author={I. Hubloue and D. Biarent and S. Abdel Kafi and G. Bejjani and C. M{\'e}lot and R. Naeije and M. Leeman},
  journal={Intensive Care Medicine},
  year={2003},
  volume={29},
  pages={1003-1006}
}
ObjectiveTo investigate the effects of endogenous endothelins on pulmonary haemodynamics and gas exchange in oleic acid lung injury.DesignProspective experimental study in dogs.SettingAnimal research laboratory in a university teaching hospital.SubjectsSeventeen anaesthetised and ventilated mongrel dogs.InterventionsNine pretreated dogs received an infusion of the endothelin A and B receptor antagonist bosentan (10 mg/kg) started before oleic acid. Eight treated dogs received bosentan started… Expand
18 Citations
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