Endothelin receptor antagonists.

@article{Motte2006EndothelinRA,
  title={Endothelin receptor antagonists.},
  author={Sophie Motte and Kathleen McEntee and Robert Naeije},
  journal={Pharmacology & therapeutics},
  year={2006},
  volume={110 3},
  pages={386-414}
}
Endothelin receptor antagonists (ERAs) have been developed to block the effects of endothelin-1 (ET-1) in a variety of cardiovascular conditions. ET-1 is a powerful vasoconstrictor with mitogenic or co-mitogenic properties, which acts through the stimulation of 2 subtypes of receptors [endothelin receptor subtype A (ETA) and endothelin receptor subtype B (ETB) receptors]. Endogenous ET-1 is involved in a variety of conditions including systemic and pulmonary hypertension (PH), congestive heart… CONTINUE READING
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