Endothelin receptor antagonists inhibit endothelin in human skin microcirculation.

  title={Endothelin receptor antagonists inhibit endothelin in human skin microcirculation.},
  author={Ren{\'e} R. Wenzel and Gregor Noll and Thomas Felix L{\"u}scher},
  volume={23 5},
Endothelin is a potent vasoconstrictor peptide produced by endothelial cells, but its role in physiology and disease is uncertain. We investigated the influence of the endothelin-A-selective receptor antagonist PD 147953 and the nonselective endothelin receptor antagonist PD 145065 on the effects of endothelin-1 and endothelin-3 in the skin microcirculation of healthy volunteers, using laser Doppler flowmetry. A double injection model was developed, allowing simultaneous injection of two… CONTINUE READING


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Cloning and expression of a cDNA encoding an endothelin receptor

  • H Arai, S Hori, I Axamori, H Ohkubo, S. Nakanishi
  • Nature
  • 1990
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