Endothelin plasma levels in acute graft rejection after heart transplantation.


BACKGROUND Endothelin is an oligopeptide of endothelial origin with potent vasoconstrictive and mitogenic properties, implicated in the pathogenesis of cyclosporine-induced hypertension, graft vasculopathy, and renal failure. Experimental animal data suggest a role for endothelin in allograft rejection also. METHODS To determine the role of endothelin in… (More)


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