Endothelin plasma levels in acute graft rejection after heart transplantation.

Abstract

BACKGROUND Endothelin is an oligopeptide of endothelial origin with potent vasoconstrictive and mitogenic properties, implicated in the pathogenesis of cyclosporine-induced hypertension, graft vasculopathy, and renal failure. Experimental animal data suggest a role for endothelin in allograft rejection also. METHODS To determine the role of endothelin in… (More)

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