Endothelin modulation of neuroeffector transmission in smooth muscle.

  title={Endothelin modulation of neuroeffector transmission in smooth muscle.},
  author={Nils Peter Wiklund and Claes U Wiklund and B Cederqvist and A Ohl{\'e}n and Per Hedqvist and Lars E. Gustafsson},
  journal={Journal of cardiovascular pharmacology},
  volume={17 Suppl 7},
In a series of muscle preparations, the peptides endothelin-1 (ET-1) and endothelin-3 (ET-3) were investigated for effects on basal muscle tone, responses to transmural nerve stimulation, and release of [3H]norepinephrine or [3H]acetylcholine. ET-1 and ET-3 contracted rat vas deferens and guinea pig ileum, ET-1 being the most potent. In the guinea pig taenia coli, ET-1 induced a relaxation whereas ET-3 was almost without relaxing effect. In the rat vas deferens, ET-1 and ET-3 enhanced… CONTINUE READING