Endothelin-like immunoreactivity in rat models of diabetes mellitus.

  title={Endothelin-like immunoreactivity in rat models of diabetes mellitus.},
  author={Kazuhiro Takahashi and Kazuhiro Suda and Hing Chung Lam and Mohammad A. Ghatei and Stephen R. Bloom},
  journal={The Journal of endocrinology},
  volume={130 1},
The factors associated with high concentrations of circulating plasma immunoreactive endothelin in patients with diabetes mellitus are unknown. Plasma and tissue (lung and kidney) immunoreactive endothelin levels were therefore measured by radioimmunoassay in three animal models of diabetes mellitus: dexamethasone-treated rats (2 mg/kg per day for 12 days), streptozotocin-treated rats (100 mg/kg, 4 days before being killed) and rats treated with both dexamethasone and streptozotocin. Plasma… CONTINUE READING

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