Endothelin levels in human amniotic fluid at mid-trimester and at term before and during spontaneous labor.

@article{Casey1993EndothelinLI,
  title={Endothelin levels in human amniotic fluid at mid-trimester and at term before and during spontaneous labor.},
  author={M. Linette Casey and Cecil E. Brown and Marlies E. W. J. Peters and Paul C. Macdonald},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={76 6},
  pages={1647-50}
}
Endothelin (ET)-1 is synthesized in human amnion and immunoreactive (ir) ET is present in amniotic fluid in concentrations 10- to 100-times those found in plasma. ET-1 is a potent uterotonin; therefore, the possibility must be considered that ET-1, derived from amnion/amniotic fluid, serves to promote the uterine contractions of human labor. In term pregnancies, after labor begins, the amniotic fluid normally becomes divided into the upper and forebag compartments as the fetal presenting part… CONTINUE READING
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