Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.

@article{Shiwen2007EndothelinIA,
  title={Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.},
  author={Xu Shi-wen and Laura A Kennedy and Elisabetta A Renzoni and George Bou-Gharios and Roland M du Bois and Carol Mary Black and Christopher P. Denton and David J. Abraham and Andrew Leask},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 12},
  pages={4189-94}
}
OBJECTIVE Fibrosis is excessive scarring caused by the accumulation and contraction of extracellular matrix proteins and is a common end pathway in many chronic diseases, including scleroderma (systemic sclerosis [SSc]). Indeed, pulmonary fibrosis is a major cause of death in SSc. Transforming growth factor beta (TGFbeta) induces endothelin 1 (ET-1) in human lung fibroblasts by a Smad-independent, JNK-dependent mechanism. The goal of this study was to assess whether ET-1 is a downstream… CONTINUE READING

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