Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products.

@article{Perico1991EndothelinID,
  title={Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products.},
  author={Norberto Perico and R P Cornejo and Ariela Benigni and B Malanchini and Jerzy Robert Ladny and Giuseppe Remuzzi},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1991},
  volume={2 1},
  pages={57-69}
}
Besides being a potent renal vasoconstrictor, endothelin causes diuresis and natriuresis. At which site along the nephron and how endothelin alters water and sodium handling in the tubule remain to be clarified. It was found that endothelin (75 pmol) given as an i.v. infusion in vivo to rats caused diuresis and urinary sodium excretion to double but did not affect glomerular filtration rate and renal plasma flow. On raising the dose of endothelin to 150 pmol, a further increase in diuresis and… CONTINUE READING

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