Endothelin-induced vascular and bronchial effects in pig airways: role in acute allergic responses.

Abstract

The effects of endothelin (ET) agonists on airway mechanics and bronchial blood flow were studied as well as the effects of mixed ET-receptor antagonist bosentan on allergen-induced airway reactions in the pig. ET agonists [ET-1, ET-3, and the ET(B) receptor-selective agonist Sarafotoxin 6c (Sf6c)] were given as intravenous injections (0.4-200 pmol/kg) to… (More)

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@article{Sylvin2002EndothelininducedVA, title={Endothelin-induced vascular and bronchial effects in pig airways: role in acute allergic responses.}, author={H. Sylvin and Eddie Weitzberg and Kjell Alving}, journal={Journal of applied physiology}, year={2002}, volume={93 5}, pages={1608-15} }