Endothelin increases myofilament Ca2+ sensitivity in alpha-toxin-permeabilized rabbit mesenteric artery.

@article{Nishimura1992EndothelinIM,
  title={Endothelin increases myofilament Ca2+ sensitivity in alpha-toxin-permeabilized rabbit mesenteric artery.},
  author={Junji Nishimura and Scott Moreland and Hwoe Young Ahn and T Kawase and Robert S. Moreland and Casey van Breemen},
  journal={Circulation research},
  year={1992},
  volume={71 4},
  pages={951-9}
}
This study was designed to investigate the mechanism of endothelin-1 (ET-1) contractions in Staphylococcus alpha-toxin-permeabilized vascular smooth muscle. Rabbit small mesenteric arteries permeabilized with alpha-toxin were mounted for isometric or isotonic force recording or were processed for determination of myosin light chain (MLC) phosphorylation levels. Addition of 100 nM ET-1 plus 10 microM GTP significantly enhanced myofilament Ca2+ sensitivity as compared with the addition of Ca2… CONTINUE READING
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