Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis.

@article{McCartney2002EndothelinIH,
  title={Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis.},
  author={Sara A. McCartney and Anne B Ballinger and Ivana Vojnovi{\'c} and Michael J G Farthing and Timothy D Warner},
  journal={Life sciences},
  year={2002},
  volume={71 16},
  pages={1893-904}
}
There have been suggestions that endothelins (ET-1, ET-2, ET-3) are involved in the pathogenesis of human inflammatory bowel disease (IBD). Furthermore, the non-selective endothelin receptor antagonist, bosentan, ameliorates colonic inflammation in TNBS colitis in rats. However, no studies have measured the tissue expression and release of endothelins in human IBD in direct comparison to experimental TNBS colitis. Mucosal biopsies were obtained from 114 patients (42 Crohn's colitis, 35… CONTINUE READING
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