Endothelin in heart failure: a promising therapeutic target?

@article{Love1997EndothelinIH,
  title={Endothelin in heart failure: a promising therapeutic target?},
  author={Michael P. Love and John J V McMurray},
  journal={Heart},
  year={1997},
  volume={77 2},
  pages={
          93-4
        }
}
The results of early acute haemodynamic studies with anti-endothelin agents are promising. Much still needs to be done, however, before endothelin antagonism is established as a therapeutic strategy in heart failure. We need to know, for example, whether the haemodynamic effects of anti-endothelin drugs are sustained. We need to ensure that there is no reflex activation of other neuroendocrine systems and, preferably, to demonstrate neuroendocrine suppression. Characterisation of the renal… CONTINUE READING
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