Endothelin in chronic heart failure: current position and future prospects.

@article{Love1996EndothelinIC,
  title={Endothelin in chronic heart failure: current position and future prospects.},
  author={Michael P. Love and John. J. V. McMurray},
  journal={Cardiovascular research},
  year={1996},
  volume={31 5},
  pages={
          665-74
        }
}
Though much has still to be learned about the various actions of endothelin-1 in human physiology, current evidence suggests an important role for the peptide in the pathophysiology of CHF. The development of novel and more effective therapeutic strategies for CHF is an important priority in cardiovascular medicine, and anti-endothelin drugs appear to offer promise in this regard. The impact of ACE inhibitors has been such that for a new treatment modality to be of real value in CHF, it will… CONTINUE READING
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