Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.

@article{Palmer2009EndothelinconvertingEI,
  title={Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.},
  author={Jennifer C. Palmer and Shabnam Baig and Patrick Gavin Kehoe and Seth Love},
  journal={The American journal of pathology},
  year={2009},
  volume={175 1},
  pages={262-70}
}
Alzheimer's disease (AD) is thought to be caused by the accumulation of amyloid beta (Abeta) peptide within the brain. Endothelin-converting enzyme-2 (ECE-2), which is expressed in neural tissues, cleaves 'big endothelin' to produce the vasoconstrictor endothelin-1. ECE-2 also degrades Abeta. We have examined ECE-2 expression in the temporal cortex of brain tissue from patients with AD, vascular dementia, and controls. Immunohistochemistry with specific antibodies showed ECE-2 to be abundant… CONTINUE READING

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