Endothelin contributes to the blood pressure rise triggered by hypoxia in severe obstructive sleep apnea.

BACKGROUND Obstructive sleep apnea (OSA) is strongly correlated with an increased risk of systemic hypertension. However, the link between systemic hypertension and nocturnal apneas remains incompletely understood. Animal studies suggest an implication of the endothelin system. The aim of the present study is to determine if endogenous endothelin plays a… CONTINUE READING