Endothelin axis polymorphisms in patients with scleroderma.

@article{Fonseca2006EndothelinAP,
  title={Endothelin axis polymorphisms in patients with scleroderma.},
  author={Carmen Fonseca and Elizabeth A. Renzoni and Piersante Sestini and Panagiotis Pantelidis and Anna L. Lagan and Christopher Bunn and Neil McHugh and Ken Ian Welsh and Roland M. du Bois and Christopher P. Denton and Carol Black and Dr.Lissa Abraham},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 9},
  pages={
          3034-42
        }
}
OBJECTIVE To evaluate the distribution of polymorphisms in the endothelin 1 (EDN1), endothelin receptor A (EDNRA) and endothelin receptor B (EDNRB) genes in systemic sclerosis (SSc; scleroderma) and SSc subsets. METHODS Two hundred five patients with SSc and 255 healthy controls were screened for polymorphisms in EDN1, EDNRA, and EDNRB, using sequence-specific primer-polymerase chain reaction. The polymorphisms studied were at the following positions: for EDN1, -1370 (T-1370G) of the promoter… CONTINUE READING
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