Endothelin axis polymorphisms in patients with scleroderma.

  title={Endothelin axis polymorphisms in patients with scleroderma.},
  author={Carmen Fonseca and Elizabeth A Renzoni and Piersante Sestini and Panagiotis Pantelidis and Anna L. Lagan and Christopher Bunn and Neil McHugh and Ken Ian Welsh and Roland M du Bois and Christopher P. Denton and Carol Black and D Abraham},
  journal={Arthritis and rheumatism},
  volume={54 9},
OBJECTIVE To evaluate the distribution of polymorphisms in the endothelin 1 (EDN1), endothelin receptor A (EDNRA) and endothelin receptor B (EDNRB) genes in systemic sclerosis (SSc; scleroderma) and SSc subsets. METHODS Two hundred five patients with SSc and 255 healthy controls were screened for polymorphisms in EDN1, EDNRA, and EDNRB, using sequence-specific primer-polymerase chain reaction. The polymorphisms studied were at the following positions: for EDN1, -1370 (T-1370G) of the promoter… CONTINUE READING

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