Endothelin antagonists.

  title={Endothelin antagonists.},
  author={Ariela Benigni and Giuseppe Remuzzi},
  volume={353 9147},
The very potent endogenous vasoconstrictor endothelin was discovered in 1988. We know now that there are three isoforms (1, 2, and 3) and two receptor subtypes (A and B). A whole range of peptide and non-peptide antagonists has been developed, some selective for A or B receptors and others with non-selective A/B antagonistic activity. So far the main application of these agents has been experimental--ie, endothelin blockers are used to throw light on disease mechanisms, most notably… CONTINUE READING

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