Endothelin and the production of cerebral vasospasm in dogs.

  title={Endothelin and the production of cerebral vasospasm in dogs.},
  author={Toshio Asano and Ichiro Ikegaki and Yasuhiro Suzuki and Shin ichi Satoh and Masato Shibuya},
  journal={Biochemical and biophysical research communications},
  volume={159 3},
We attempted to determine whether or not endothelin (ET) plays a physiological role in cerebral vasospasm. ET (10(-11) - 3 x 10(-8) M) induced a concentration-dependent contraction in isolated canine basilar arteries. Intracisternal injection of 10 to 1,000 pmol ET into dogs induced a dose-dependent decrease in the basilar artery diameter, as measured angiographically on the 1st day. On the 3rd day after the injection of ET (10 pmol), the diameter of the basilar artery had diminished to 76% of… CONTINUE READING