Endothelin and the heart in health and diseases

@article{Miyauchi2019EndothelinAT,
  title={Endothelin and the heart in health and diseases},
  author={Takashi Miyauchi and Satoshi Sakai},
  journal={Peptides},
  year={2019},
  volume={111},
  pages={77-88}
}
HIGHLIGHTSEndothelin‐1 (ET‐1) causes potent vasoconstriction and vasoproliferation.Cardiomyocytes produce ET‐1, which causes a hypertrophic activity of cardiomyocytes.ET‐1 acts via activation of two receptor subtypes, ETA and ETB receptors.ET receptor antagonists (ERA) are currently in clinical use for pulmonary hypertension.Heart failure, renal diseases, hypertension, etc are further target diseases of ERA. ABSTRACT Endothelin‐1 (ET‐1), a 21‐amino acid peptide, was initially identified in 1988… Expand
17 Citations
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Recent updates on novel therapeutic targets of cardiovascular diseases
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  • Medicine
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  • 2020
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