Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis.

@article{Tsuruoka2006EndothelinAN,
  title={Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis.},
  author={Shuichi Tsuruoka and Seiji Watanabe and Jeffrey M. Purkerson and Akio Fujimura and George J. Schwartz},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={291 4},
  pages={F866-73}
}
Endothelin (ET) and nitric oxide (NO) modulate ion transport in the kidney. In this study, we defined the function of ET receptor subtypes and the NO guanylate cyclase signaling pathway in mediating the adaptation of the rabbit cortical collecting duct (CCD) to metabolic acidosis. CCDs were perfused in vitro and incubated for 3 h at pH 6.8, and bicarbonate transport or cell pH was measured before and after acid incubation. Luminal chloride was reversibly removed to isolate H(+) and HCO(3… CONTINUE READING