Endothelin and its suspected role in the pathogenesis and possible treatment of glaucoma.

@article{Shoshani2012EndothelinAI,
  title={Endothelin and its suspected role in the pathogenesis and possible treatment of glaucoma.},
  author={Yochai Z Shoshani and Alon Harris and Mohammadali M Shoja and Deepam Rusia and Brent Siesky and Yoel Arieli and Barbara M Wirostko},
  journal={Current eye research},
  year={2012},
  volume={37 1},
  pages={1-11}
}
PURPOSE To review the role of endothelin in intraocular pressure control, its effect on the trabecular meshwork (TM) and the outflow facility, effect on ocular blood flow and vascular regulation and the potential role of endothelin-1 (ET-1) antagonism in the therapeutic paradigm of glaucoma. METHODS A thorough review of the medical literature and a meta-analysis on the level of ET-1 in OAG patients in an attempt to demonstrate the evolving importance of endothelin in glaucoma. RESULTS ET-1… CONTINUE READING
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