Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy.

@article{Ito1997EndothelinAA,
  title={Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy.},
  author={Norihisa Ito and Yutaka Kagaya and Ellen O. Weinberg and William H. Barry and Beverly H. Lorell},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 1},
  pages={125-35}
}
We compared the effects of endothelin-1 (ET-1) on intracellular pH, intracellular [Ca2+]i, and cell contraction in hypertrophied adult ventricular myocytes from ascending aortic banded rats and age-matched controls. Intracellular pH (pH(i)) was measured in individual myocytes with SNARF-1, and [Ca2+]i was measured with indo-1, simultaneous with cell motion. Experiments were performed at 36 degrees C in myocytes paced at 0.5 Hz in Hepes-buffered solution (pH(o) 7.40) containing 1.2 mM CaCl2. At… CONTINUE READING
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Vaughan-Joner. 1992. role of bicarbonate in pH recovery from intracellular acidosis in the guinea pig myocyte

  • D. Lagadic-Gossman, K. J. Buckler, R.D
  • J. Physiol. (Lond.)
  • 1992
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