Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach.

@article{Nakamura2003EndothelinEA,
  title={Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach.},
  author={Kumiko Nakamura and Shoshiro Okada and Kunihiko Yokotani},
  journal={Journal of pharmacological sciences},
  year={2003},
  volume={91 1},
  pages={34-40}
}
We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach. The release of noradrenaline evoked by electrical stimulation of the gastric postganglionic sympathetic nerves (at 2.5 Hz for 1 min) was inhibited by endothelin-1 (10(-)(10) - 10(-)(8) M), endothelin-3 (10(-)(9) - 10(-)(8) M) and sarafotoxin S6c (a highly selective agonist of endothelin ET(B… CONTINUE READING