Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice.

@article{Guimares2002EndothelinER,
  title={Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice.},
  author={C. Guimar{\~a}es and P. Trentin and G. Rae},
  journal={Clinical science},
  year={2002},
  volume={103 Suppl 48},
  pages={
          340S-344S
        }
}
The receptors underlying the endothelin-dependent component of lung plasma extravasation and leucocyte infiltration induced by oleic acid were assessed in mice. Oleic acid (1 mg.kg(-1) intravenously), but not endothelin-1 (up to 1 nmol.kg(-1) intravenously), increased accumulation of Evans blue in the lungs (excluding the trachea and main bronchi) from 11.8+/-3.9 to 98.6+/-10.7 microg 1 h after injection. Bosentan, the antagonist of endothelin receptors (ET(A) and ET(B)) or the selective ET(B… Expand
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