Endothelin-B receptor-mediated Ca2+ signaling in human melanocytes

  title={Endothelin-B receptor-mediated Ca2+ signaling in human melanocytes},
  author={Hee-Young Kang and W H Kang and C.-O. Lee},
  journal={Pfl{\"u}gers Archiv},
 The mechanism of an endothelin-1- (ET-1-) induced intracellular Ca2+ ([Ca2+]i) increase and the receptor subtype(s) responsible for this effect in single human melanocytes were studied using fura-2/AM. ET-1 induced a transient increase in [Ca2+]i in a concentration-dependent manner. The transient [Ca2+]i increase was followed by a sustained plateau level of [Ca2+]i which was higher than the initial [Ca2+]i level. IRL-1620, a specific ET-B receptor agonist, increased [Ca2+]i in a dose-dependent… CONTINUE READING