Endothelin B receptor expression in human astrocytoma: association with clinicopathological variables and survival outcomes.

@article{Shen2011EndothelinBR,
  title={Endothelin B receptor expression in human astrocytoma: association with clinicopathological variables and survival outcomes.},
  author={Chenfu Shen and Liang Yang and Xian-rui Yuan},
  journal={The International journal of neuroscience},
  year={2011},
  volume={121 11},
  pages={626-31}
}
The endothelin (ET) axis has been implicated in astrocytoma growth and progression. Selective ETB receptor antagonists blocked proliferation and induced apoptosis in astrocytoma cell lines, suggesting that the ETB receptor could be a therapeutic target for astrocytomas. In the present study, we explored the association of the ETB receptor expression with clinicopathological variables and the prognosis of human astrocytomas, by examining the ETB receptor expression and Ki-67 staining in 71… CONTINUE READING
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