Endothelin B receptor antagonists block proliferation and induce apoptosis in glioma cells.

@article{Paolillo2010EndothelinBR,
  title={Endothelin B receptor antagonists block proliferation and induce apoptosis in glioma cells.},
  author={Mayra Paolillo and Marika A. Russo and Daniela Curti and Cristina Lanni and Sergio Schinelli},
  journal={Pharmacological research},
  year={2010},
  volume={61 4},
  pages={306-15}
}
The proliferative and antiapoptotic actions of endothelin (ET)-1 in cancer cells have been documented and ET receptor antagonists have been exploited as potential anticancer drugs. Glioblastoma cell lines express both ETA and ETB receptors and previous works have shown that ETB receptors are involved in the proliferation of different cancer cell types. In this study we have investigated the effects of two structurally unrelated ETB receptor antagonists, BQ788 and A192621, on cell survival… CONTINUE READING