Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus.

@article{Coceani1999EndothelinAR,
  title={Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus.},
  author={Flavio Coceani and Y Alexander Liu and Eric Seidlitz and Linda S. Kelsey and Tomoyuki Kuwaki and Cameron A. Ackerley and Masashi Yanagisawa},
  journal={The American journal of physiology},
  year={1999},
  volume={277 4 Pt 2},
  pages={H1521-31}
}
In vitro and in vivo techniques were developed with genetically modified mice to determine whether endothelin-1 (ET-1) functions as an O2 mediator in closure of the ductus arteriosus (DA) at birth. Wild-type CD-1 and 129/SvEv mice with ETA receptor -/-, +/-, and +/+ genotypes were used. Isolated DA from term ETA +/+ fetuses contracted to O2 (5-95%) and a thromboxane A2 analog (ONO-11113, 0.1 μM). Instead, ET-1 elicited a dual response with weak relaxation (0.1 nM) preceding contraction (1-100… CONTINUE READING