Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis.

@article{Eibl2002EndothelinAB,
  title={Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis.},
  author={Guido Eibl and Bence Forg{\'a}cs and Hubert Georg Hotz and Heinz Johannes Buhr and Thomas Foitzik},
  journal={Pancreas},
  year={2002},
  volume={25 2},
  pages={
          e15-20
        }
}
INTRODUCTION Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM To find out which endothelin receptor subtype (ET-A or ET-B) mediates the changes in CapPerm. METHODOLOGY Severe AP was induced in rats by intraductal bile salt infusion and i.v… CONTINUE READING
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