Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro.

@article{AlJiffry2002Endothelin3IB,
  title={Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro.},
  author={Bilal O. Al-Jiffry and James Toouli and G. T. P. Saccone},
  journal={Journal of gastroenterology and hepatology},
  year={2002},
  volume={17 3},
  pages={
          324-31
        }
}
BACKGROUND Endothelins are produced by gallbladder epithelial cells, suggesting a role in the regulation of gallbladder function. AIMS To characterize the effect of endothelin-3 (ET-3) on human and Australian possum gallbladder contractility and identify the receptor(s) involved. METHODS Human and possum gallbladder muscle strips were exposed to cumulative concentrations of ET-3 (10 pmol/L-100 nmol/L). Strips were pretreated with either tetrodotoxin (TTX) (1 micro mol/L), the selective ET… CONTINUE READING
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