Endothelin-3 directly affects neurons in the anteroventral third ventricle region and supraoptic nucleus of the rat hypothalamus in vitro.

@article{Yamashita1991Endothelin3DA,
  title={Endothelin-3 directly affects neurons in the anteroventral third ventricle region and supraoptic nucleus of the rat hypothalamus in vitro.},
  author={Haruyo Yamashita and Satoshi Yamamoto and Kiyotoshi Inenaga and Hiroshi Kannan},
  journal={Journal of cardiovascular pharmacology},
  year={1991},
  volume={17 Suppl 7},
  pages={
          S200-2
        }
}
Extracellular recordings were made from anteroventral third ventricle (AV3V) and supraoptic nucleus (SON) neurons of rat hypothalamus in slice preparations. ET-3 was applied at concentrations of 10(-10) to 3 x 10(-7) M. Of 119 AV3V neurons tested, 21 (18%) were excited, 8 (6%) were slightly inhibited, and 90 (76%) were unaffected. The threshold concentration to evoke responses was approximately 10(-8) M. Excitatory responses of the AV3V neurons to ET-3 remained in a Ca(2+)-free medium. Of 120… CONTINUE READING