Endothelin-3-dependent pulmonary vasoconstriction in monocrotaline-induced pulmonary arterial hypertension.

@article{Sauvageau2008Endothelin3dependentPV,
  title={Endothelin-3-dependent pulmonary vasoconstriction in monocrotaline-induced pulmonary arterial hypertension.},
  author={St{\'e}phanie Sauvageau and Eric Thorin and Louis Villeneuve and Jocelyn Dupuis},
  journal={Peptides},
  year={2008},
  volume={29 11},
  pages={2039-45}
}
Blockade of the endothelin (ET) system is beneficial in pulmonary arterial hypertension (PAH). The contribution of ET-3 and its interactions with ET receptors have never been evaluated in the monocrotaline (MCT)-induced model of PAH. Vasoreactivity of pulmonary arteries was investigated; ET-3 localization was determined by confocal imaging and gene… CONTINUE READING