Endothelin-1 released by vascular smooth muscle cells enhances vascular responsiveness of rat mesenteric arterial bed exposed to high perfusion flow.

@article{Russo1999Endothelin1RB,
  title={Endothelin-1 released by vascular smooth muscle cells enhances vascular responsiveness of rat mesenteric arterial bed exposed to high perfusion flow.},
  author={Domenico Russo and Roberto Minutolo and Carla Clienti and Luca De Nicola and Carmela Iodice and Francesco Savino and Vittorio E. Andreucci},
  journal={American journal of hypertension},
  year={1999},
  volume={12 11 Pt 1},
  pages={1119-23}
}
Vasodilation of resistance vessels ensues in response to increased perfusion flow to maintain tissue perfusion. The flow-induced vasodilation is mainly dependent on nitric oxide (NO), which also regulates vascular responsiveness to vasoconstrictors. Besides NO, however; high flow increases endothelin-1 (ET-1) production from endothelial cells. It is likely, therefore, that the interaction between NO and ET-1 may play a critical role in the control of arterial vascular tone under high perfusion… CONTINUE READING

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