Endothelin-1 production by the canine macrophage cell line DH82: enhanced production in response to microbial challenge.

@article{Divino2010Endothelin1PB,
  title={Endothelin-1 production by the canine macrophage cell line DH82: enhanced production in response to microbial challenge.},
  author={Jeffrey N. Divino and Kashmira Satish Chawla and Christina M da Silva and Ashley M Bjorge and Andrew Brittingham},
  journal={Veterinary immunology and immunopathology},
  year={2010},
  volume={136 1-2},
  pages={127-32}
}
Endothelin-1 (ET-1) is a potent vasoconstrictive peptide which plays an important role in regulating mammalian cardiovascular development and homeostasis. Originally identified as a factor released by vascular endothelial cells, ET-1 is now recognized as a product of numerous cells and tissues with demonstrated involvement in an array of physiological and pathological processes. An area of great interest is the production of ET-1 by mononuclear cells (monocytes and macrophages) and its role in… CONTINUE READING

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