Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade.

@article{Yang1999Endothelin1PH,
  title={Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade.},
  author={Zhihong Yang and N Krasnici and Thomas Felix L{\"u}scher},
  journal={Circulation},
  year={1999},
  volume={100 1},
  pages={5-8}
}
BACKGROUND Endothelin-1 (ET-1) is a potent vasoconstrictor. However, its mitogenic effects on vascular smooth muscle cells (SMCs) remain controversial. We investigated the role of ET-1 in human SMC growth and its synergistic effect with platelet-derived growth factor (PDGF). METHODS AND RESULTS Human aortic SMCs were cultured and cell proliferation was assayed by [3H]thymidine incorporation. PDGF receptor expression, activation of mitogen-activated protein kinase (MAPK), cell cycle regulators… CONTINUE READING
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