Endothelin-1 levels are increased in sera and lesional skin extracts of psoriatic patients and correlate with disease severity.

@article{Bonifati1998Endothelin1LA,
  title={Endothelin-1 levels are increased in sera and lesional skin extracts of psoriatic patients and correlate with disease severity.},
  author={Claudio Bonifati and Anna Mussi and M. Carducci and A Pittarello and L D'auria and Alberto Venuti and Anna Bagnato and Debora Salani and M. Andreoli A. Agnoli C. Fazio and Franco Ameglio},
  journal={Acta dermato-venereologica},
  year={1998},
  volume={78 1},
  pages={22-6}
}
Endothelins (ETs), in addition to their systematical activities, exert important functions at the skin level, such as increase of keratinocyte proliferation, neo-angiogenesis and leukocyte chemotaxis, which are among the main characteristics of psoriasis. To assess a possible ET-1 involvement in plaque-type psoriasis, ET-1 determinations were carried out in… CONTINUE READING