Endothelin-1 is a potent activator of nonselective cation currents in human bronchial smooth muscle cells.

@article{Oonuma2000Endothelin1IA,
  title={Endothelin-1 is a potent activator of nonselective cation currents in human bronchial smooth muscle cells.},
  author={Hitoshi Oonuma and Toshiaki Nakajima and Taiji Nagata and Kuniaki Iwasawa and Yi-he Wang and Hiroaki Hazama and Yutaka Morita and Kazuhiko Yamamoto and Reiko Nagai and Masao Omata},
  journal={American journal of respiratory cell and molecular biology},
  year={2000},
  volume={23 2},
  pages={213-21}
}
The effects of endothelin (ET)-1 on cultured human bronchial smooth muscle cells (HBSMC) were investigated and compared with those of histamine, using the patch clamp techniques and measurements of intracellular Ca(2+) ([Ca(2+)](i)). Both ET-1 and histamine caused an initial transient elevation of [Ca(2+)](i) by Ca(2+) mobilization, followed by a sustained rise due to Ca(2+) entry. Nicardipine inhibited the sustained phase, but La(3+) abolished it. With low ethyleneglycol-bis-(beta-aminoethyl… CONTINUE READING
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