Endothelin-1 inhibits and enhances contraction of porcine coronary arterial strips with an intact endothelium.

Abstract

Using front-surface fluorometry and fura-2-loaded porcine coronary arterial strips with an intact endothelium, changes in cytosolic Ca2+ concentrations ([Ca2+]i) and tension of smooth muscle were simultaneously monitored in an attempt to determine the vasoactive properties of endothelin-1 (ET-1). ET-1 in low concentrations (0.1-1nM) caused a significant… (More)

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@article{UshioFukai1992Endothelin1IA, title={Endothelin-1 inhibits and enhances contraction of porcine coronary arterial strips with an intact endothelium.}, author={Masuko Ushio-Fukai and Johji Nishimura and Hideo Aoki and S. Kobayashi and Hideo Kanaide}, journal={Biochemical and biophysical research communications}, year={1992}, volume={184 1}, pages={518-24} }