Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase.

@article{Sun2014Endothelin1IA,
  title={Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase.},
  author={Xutong Sun and Sanjiv Kumar and Shruti S. Sharma and Saurabh Aggarwal and Qing Lu and Christine Gross and O. S. Rafikova and Sung Gon Lee and Sridevi Dasarathy and Yali Hou and Mary Louise Meadows and Weihong Han and Yunchao Su and Jeffrey R. Fineman and S. M. Black},
  journal={American journal of respiratory cell and molecular biology},
  year={2014},
  volume={50 6},
  pages={1084-95}
}
Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been elucidated. Endothelin (ET)-1, an endothelial-derived vasoconstrictor peptide, is increased in PH, and has been shown to play an important role in the oxidative stress associated with PH. Thus, in this study, we investigated whether there was a… CONTINUE READING